pI: 6.4888 |
Length (AA): 293 |
MW (Da): 33075 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
31 | 222 | 1nlt (A) | 148 | 337 | 43.00 | 0 | 1 | 1.04849 | 1.2 |
106 | 234 | 2b26 (C) | 191 | 348 | 34.00 | 0 | 1 | 0.793673 | -0.07 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126883)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G22060 | chaperone protein dnaJ 2 |
Arabidopsis thaliana | AT3G44110 | chaperone protein dnaJ 3 |
Babesia bovis | BBOV_IV009890 | DnaJ chaperone, putative |
Brugia malayi | Bm1_12110 | DnaJ protein |
Brugia malayi | Bm1_00180 | DnaJ chaperonine |
Candida albicans | CaO19.8136 | likely heat-shock protein (DnaJ) similar to S. cerevisiae YDJ1 (YNL064C) |
Candida albicans | CaO19.506 | likely heat-shock protein (DnaJ) similar to S. cerevisiae YDJ1 (YNL064C) |
Caenorhabditis elegans | CELE_F39B2.10 | Protein DNJ-12 |
Caenorhabditis elegans | CELE_T05C3.5 | Protein DNJ-19 |
Cryptosporidium hominis | Chro.80434 | DNAJ domain protein |
Cryptosporidium parvum | cgd8_3770 | DNAJ like chaperone |
Dictyostelium discoideum | DDB_G0280037 | heat shock protein |
Drosophila melanogaster | Dmel_CG8863 | DnaJ-like-2 |
Echinococcus granulosus | EgrG_000101800 | dnaJ subfamily A |
Entamoeba histolytica | EHI_079720 | DnaJ family protein |
Entamoeba histolytica | EHI_073780 | DNAJ homolog subfamily A member 2, putative |
Entamoeba histolytica | EHI_151260 | DnaJ family protein |
Echinococcus multilocularis | EmuJ_000101800 | dnaJ subfamily A |
Giardia lamblia | GL50803_9808 | Chaperone protein DnaJ |
Homo sapiens | ENSG00000140403 | DnaJ (Hsp40) homolog, subfamily A, member 4 |
Homo sapiens | ENSG00000069345 | DnaJ (Hsp40) homolog, subfamily A, member 2 |
Homo sapiens | 3301 | DnaJ (Hsp40) homolog, subfamily A, member 1 |
Leishmania braziliensis | LbrM.27.2610 | heat shock protein DNAJ, putative |
Leishmania braziliensis | LbrM.21.0550 | DnaJ protein, putative |
Leishmania donovani | LdBPK_272350.1 | heat shock protein DNAJ, putative |
Leishmania donovani | LdBPK_210550.1 | DnaJ protein, putative |
Leishmania infantum | LinJ.21.0550 | DnaJ protein, putative |
Leishmania infantum | LinJ.27.2350 | heat shock protein DNAJ, putative |
Leishmania major | LmjF.21.0490 | DnaJ protein, putative |
Leishmania major | LmjF.27.2400 | heat shock protein DNAJ, putative |
Leishmania mexicana | LmxM.27.2400 | heat shock protein DNAJ, putative |
Leishmania mexicana | LmxM.21.0490 | DnaJ protein, putative |
Loa Loa (eye worm) | LOAG_08462 | DnaJ protein |
Loa Loa (eye worm) | LOAG_00474 | DnaJ chaperonine |
Loa Loa (eye worm) | LOAG_07485 | hypothetical protein |
Mus musculus | ENSMUSG00000031701 | DnaJ (Hsp40) homolog, subfamily A, member 2 |
Mus musculus | ENSMUSG00000028410 | DnaJ (Hsp40) homolog, subfamily A, member 1 |
Mus musculus | ENSMUSG00000032285 | DnaJ (Hsp40) homolog, subfamily A, member 4 |
Neospora caninum | NCLIV_055170 | DnaJ domain containing protein, related |
Oryza sativa | 4333580 | Os03g0648400 |
Oryza sativa | 4336584 | Os04g0549600 |
Oryza sativa | 4330201 | Os02g0656500 |
Oryza sativa | 4334359 | Os03g0787300 |
Plasmodium berghei | PBANKA_0610900 | HSP40, subfamily A, putative |
Plasmodium falciparum | PF3D7_1437900 | HSP40, subfamily A |
Plasmodium knowlesi | PKNH_0424600 | HSP40, subfamily A, putative |
Plasmodium vivax | PVX_084650 | DnaJ domain containing protein |
Plasmodium yoelii | PY02476 | DnaJ homolog |
Saccharomyces cerevisiae | YNL064C | type I HSP40 co-chaperone YDJ1 |
Schistosoma japonicum | Sjp_0016830 | ko:K09502 DnaJ homolog, subfamily A, member 1, putative |
Schistosoma mansoni | Smp_035200.1 | hsp40 subfamily A members 124 |
Schistosoma mansoni | Smp_035200.4 | hsp40 subfamily A members 124 |
Schistosoma mansoni | Smp_035200.3 | hsp40 subfamily A members 124 |
Schistosoma mansoni | Smp_035200.2 | hsp40 subfamily A members 124 |
Schmidtea mediterranea | mk4.023390.00 | |
Schmidtea mediterranea | mk4.005212.00 | |
Schmidtea mediterranea | mk4.002651.02 | |
Schmidtea mediterranea | mk4.000960.00 | |
Schmidtea mediterranea | mk4.018720.00 | |
Schmidtea mediterranea | mk4.042143.00 | |
Trypanosoma brucei gambiense | Tbg972.10.2780 | chaperone protein DNAj, putative |
Trypanosoma brucei gambiense | Tbg.972.2.3190 | chaperone protein DNAj, putative |
Trypanosoma brucei | Tb927.2.5160 | chaperone protein DnaJ, putative |
Trypanosoma brucei | Tb927.10.2290 | chaperone protein DnaJ, putative |
Trypanosoma congolense | TcIL3000_2_1270 | chaperone protein DnaJ, putative |
Trypanosoma cruzi | TcCLB.511367.138 | chaperone DNAJ protein, putative |
Trypanosoma cruzi | TcCLB.511627.110 | heat shock protein DNAJ, putative |
Toxoplasma gondii | TGME49_311240 | DnaJ family chaperone, putative |
Theileria parva | TP01_0706 | dnaJ protein, putative |
Trichomonas vaginalis | TVAG_066950 | DNAj/HSP40, putative |
Trichomonas vaginalis | TVAG_150550 | DNAj/HSP40, putative |
Trichomonas vaginalis | TVAG_305730 | chaperone protein DNAj, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.2.5160 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.2.5160 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.2.5160 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.2.5160 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.10.2290 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.2290 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.2290 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.2290 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F39B2.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
TGME49_311240 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | DnaJ (Hsp40) homolog, subfamily A, member 1 | Compounds | References |